We showed that the SCL transcription factor, a member of the basic helix-loop-helix family of proteins, is important for the long-term maintenance of HSC by keeping these cells in a quiescent state, which could protect them against damage caused by the environment.
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SCL plays also a critical role in blood cell formation, by nucleating a large transcriptional complex on DNA with its partner LMO2. We seeks to determine which proteins associate with SCL to influence its activity and to understand how SCL and LMO2 influence normal hematopoietic cell fate.
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